Neurobiology of Disease A Promising Therapeutic Approach for Multiple Sclerosis: Recombinant T-Cell Receptor Ligands Modulate Experimental Autoimmune Encephalomyelitis by Reducing Interleukin-17 Production and Inhibiting Migration of Encephalitogenic Cells into the CNS
نویسندگان
چکیده
Sushmita Sinha,1,2 Sandhya Subramanian,1 Thomas M. Proctor,1,7 Laurie J. Kaler,1 Marjorie Grafe,3,4 Rony Dahan,2,3 Jianya Huan,2,7 Arthur A. Vandenbark,1,2,5,7 Gregory G. Burrows,2,6,7 and Halina Offner1,2,4,7 1Neuroimmunology Research, Veterans Affairs Medical Center, Portland, Oregon 97239, and Departments of 2Neurology, 3Pathology, 4Anesthesiology and Perioperative Medicine, 5Molecular Microbiology and Immunology, and 6Biochemistry and Molecular Biology and 7Tykeson MS Research Laboratory, Oregon Health & Science University, Portland, Oregon 97239
منابع مشابه
EBI2 Is Highly Expressed in Multiple Sclerosis Lesions and Promotes Early CNS Migration of Encephalitogenic CD4 T Cells.
Arrival of encephalitogenic T cells at inflammatory foci represents a critical step in development of experimental autoimmune encephalomyelitis (EAE), the animal model for multiple sclerosis. EBI2 and its ligand, 7α,25-OHC, direct immune cell localization in secondary lymphoid organs. CH25H and CYP7B1 hydroxylate cholesterol to 7α,25-OHC. During EAE, we found increased expression of CH25H by mi...
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تاریخ انتشار 2007